Estimating the causal tissues for complex traits and diseases
Abstract
How to interpret the biological causes underlying the predisposing markers identified through genome-wide association studies (GWAS) remains an open question. One direct and powerful way to assess the genetic causality behind GWAS is through analysis of expression quantitative trait loci (eQTLs). Here we describe a new approach to estimate the tissues behind the genetic causality of a variety of GWAS traits, using the cis-eQTLs in 44 tissues...
Paper Details
Title
Estimating the causal tissues for complex traits and diseases
Published Date
Oct 23, 2017
Journal
Volume
49
Issue
12
Pages
1676 - 1683
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