Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis

eLife7.70
Volume: 8
Published: Jan 31, 2019
Abstract
Bacterial metabolism is fundamental to survival and pathogenesis. We explore how Mycobacterium tuberculosis utilises amino acids as nitrogen sources, using a combination of bacterial physiology and stable isotope tracing coupled to mass spectrometry metabolomics methods. Our results define core properties of the nitrogen metabolic network from M. tuberculosis, such as: (i) the lack of homeostatic control of certain amino acid pool sizes; (ii)...
Paper Details
Title
Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis
Published Date
Jan 31, 2019
Journal
Volume
8
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