Intratumoral interleukin-6 and myeloid cell subsets within the cholangiocarcinoma tumor microenvironment
Abstract
Background: Cholangiocarcinoma (CC) is an aggressive malignancy largely resistant to conventional therapy. Although immunotherapy elicits responses in some patients, the immune tumor microenvironment remains understudied. In particular, the cytokine interleukin-6 (IL-6) acts in an autocrine/paracrine manner to enhance the growth of CC cells. Our laboratory has also shown IL-6 is instrumental for expanding myeloid-derived suppressor cells (MDSCs)...
Paper Details
Title
Intratumoral interleukin-6 and myeloid cell subsets within the cholangiocarcinoma tumor microenvironment
Published Date
Mar 1, 2019
Journal
Volume
21
Pages
S7 - S7
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Notes
History