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Cardiovascular outcomes related to social defeat stress: New insights from resilient and susceptible rats

Published on Nov 1, 2019in Neurobiology of Stress
· DOI :10.1016/j.ynstr.2019.100181
Gessynger Morais-Silva4
Estimated H-index: 4
(UFSCar: Federal University of São Carlos),
Willian Costa-Ferreira3
Estimated H-index: 3
(UFSCar: Federal University of São Carlos)
+ 3 AuthorsMarcelo Tadeu Marin11
Estimated H-index: 11
(UFSCar: Federal University of São Carlos)
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Abstract
Abstract Stress exposure is an important risk factor for psychiatric and cardiovascular disorders. Two phenotypes related to coping with stress can be observed in rodents that experience chronic social defeat stress (SDS): susceptible, showing social avoidance and behavioral changes related to depression, and resilient, showing none of these alterations. Moreover, a strong correlation exists between depression and the development of or mortality due to cardiovascular diseases. Nevertheless, little is known about cardiovascular alterations related to SDS exposure in those phenotypes or their correlation with depressive-like behaviors. Using a chronic SDS protocol followed by the social interaction test, we identified Wistar rats as resilient or susceptible to SDS. Susceptible animals showed increased depressive-like behaviors with resting tachycardia and decreased heart rate variability (HRV) due to increased sympathetic tone in the heart and a less effective baroreflex. In contrast, resilient rats were protected from these alterations by increased vagal tone, resulting in greater HRV values. To our knowledge, our study is the first to indicate that harmful cardiovascular outcomes are related to depressive-like behaviors in susceptible rats and to suggest a mechanism by which resilient rats are protected from these changes. Also, our results suggest that enhanced HRV and vagal tone may be an important trait in resilient individuals.
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References98
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Published on Oct 1, 2018in Current opinion in behavioral sciences
Orna Issler8
Estimated H-index: 8
(ISMMS: Icahn School of Medicine at Mount Sinai),
Eric J. Nestler154
Estimated H-index: 154
(ISMMS: Icahn School of Medicine at Mount Sinai)
Depression is a prevalent, devastating psychiatric disorder which women are twice as likely to suffer as men. Yet, until recently, most of the mechanistic studies shedding light on the molecular pathways involved in depression have focused on males, both animals and humans. It has been established that women have a more sensitive stress response, and that sex hormones contribute to depression onset. Recent genome-wide studies on human and mouse brain tissue have revealed that the overlap in the ...
Published on Oct 1, 2018in Mindfulness3.00
Xi Luo2
Estimated H-index: 2
(CWNU: China West Normal University),
Lei Qiao2
Estimated H-index: 2
(SWU: Southwest University),
Xianwei Che3
Estimated H-index: 3
(Monash University)
Self-compassion has increasingly been recognized to buffer stress and promote emotional health. However, few studies have examined the influences of self-compassion on physiological stress response. The current study aimed to investigate the impact of self-reported self-compassion on physiological stress response and negative affect induced in a laboratory setting. Healthy male participants (N = 34, Asians) were grouped into high (N = 17, age: mean = 19.65, SD = 0.59) or low (N = 17, age: mean =...
Published on Apr 6, 2018in Frontiers in Neuroscience3.65
Luca Carnevali13
Estimated H-index: 13
(University of Parma),
Julian Koenig17
Estimated H-index: 17
(University of Bern)
+ 1 AuthorsCristina Ottaviani18
Estimated H-index: 18
(Sapienza University of Rome)
Stressful life events are an important cause of psychopathology. Humans exposed to aversive or stressful experiences show considerable inter-individual heterogeneity in their responses. However, the majority does not develop stress-related psychiatric disorders. The dynamic processes encompassing positive and functional adaptation in the face of significant adversity have been broadly defined as resilience. Traditionally, the assessment of resilience has been confined to self-report measures, bo...
Published on Mar 1, 2018in European Journal of Clinical Investigation2.78
Marijana Tadic16
Estimated H-index: 16
(Charité),
Cesare Cuspidi42
Estimated H-index: 42
(University of Milan),
Guido Grassi76
Estimated H-index: 76
(University of Milano-Bicocca)
Jonas O. Vieira2
Estimated H-index: 2
(UFSCar: Federal University of São Carlos),
Josiane O. Duarte5
Estimated H-index: 5
(UFSCar: Federal University of São Carlos)
+ 3 AuthorsCarlos C. Crestani19
Estimated H-index: 19
(UFSCar: Federal University of São Carlos)
Abstract This study investigated the physiological, somatic and behavioral changes evoked by daily exposure to the same type of stressor (homotypic) or different aversive stressor stimuli (heterotypic) in male and female rats. For this, adult Wistar rats were subjected to a 10 days regimen of repeated restraint stress (RRS, homotypic stressor) or chronic variable stress (CVS, heterotypic stressor). Effects evoked by CVS included: (i) adrenal hypertrophy and decreased body weight gain in male ani...
Published on Jan 1, 2018in Journal of Psychosomatic Research2.72
Alexander Lischke4
Estimated H-index: 4
(University of Greifswald),
Robert Jacksteit3
Estimated H-index: 3
+ 3 AuthorsMatthias Weippert10
Estimated H-index: 10
(University of Rostock)
Abstract Objective Psychosocial stress is associated with substantial morbidity and mortality. Accordingly, there is a growing interest in biomarkers that indicate whether individuals show adaptive (i.e., stress-buffering and health-promoting) or maladaptive (i.e., stress-escalating and health-impairing) stress reactions in social contexts. As heart rate variability (HRV) has been suggested to be a biomarker of adaptive behavior during social encounters, it may be possible that inter-individual ...
Published on Dec 22, 2017in Frontiers in Neuroscience3.65
Susan M. Barman24
Estimated H-index: 24
(MSU: Michigan State University),
Bill J. Yates39
Estimated H-index: 39
(University of Pittsburgh)
Sympathetic nerve activity (SNA) contributes appreciably to the control of physiological function, such that pathological alterations in SNA can lead to a variety of diseases. The goal of this review is to discuss the characteristics of SNA, briefly review the methodology that has been used to assess SNA and its control, and to describe the essential role of neurophysiological studies in conscious animals to provide additional insights into the regulation of SNA. Studies in both humans and anima...
Published on Dec 1, 2017in Scientific Reports4.01
Danai Riga7
Estimated H-index: 7
(VU: VU University Amsterdam),
Leanne J.M. Schmitz3
Estimated H-index: 3
(VU: VU University Amsterdam)
+ 2 AuthorsSabine Spijker33
Estimated H-index: 33
(VU: VU University Amsterdam)
Major Depression is a prevalent mental disorder that is characterized by negative mood and reduced motivation, and frequently results in social withdrawal and memory-related deficits. Repeated stressors, such as adverse life events, increase the risk for development of the disorder. Consequently, individual variability in stress response greatly weighs on depression-vulnerability and -resilience. Here, we employed the social defeat-induced persistent stress (SDPS) paradigm to identify depression...
Published on Sep 1, 2017in The Lancet59.10
E. Theo Vos99
Estimated H-index: 99
(UW: University of Washington),
Amanuel Alemu Abajobir23
Estimated H-index: 23
+ 724 AuthorsSemaw Ferede Abera35
Estimated H-index: 35
(Mekelle University)
Summary Background As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. Methods We estimated prevalence and incidence fo...
Published on Jun 22, 2017in PLOS ONE2.78
Raf H.M. van Hoof4
Estimated H-index: 4
,
Evelien Hermeling11
Estimated H-index: 11
+ 8 AuthorsSylvia Heeneman33
Estimated H-index: 33
To investigate the effect of a heart rate (HR) lowering agent (Ivabradine) on features of atherosclerotic plaque vulnerability with magnetic resonance imaging (MRI), ultrasound imaging, and histology. Atherosclerosis was induced in the abdominal aorta of 19 rabbits. Nine rabbits were treated with Ivabradine (17 mg/kg/day) during the entire study period. At week 14, imaging was performed. Plaque size was quantified on contrast-enhanced T1-weighted MR images. Microvascular flow, density, and perme...
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