Extracellular vesicle-mediated macrophage activation: An insight into the mechanism of thioredoxin-mediated immune activation
Abstract
Extracellular vesicles (EVs) generated from redox active anticancer drugs are released into the extracellular environment. These EVs contain oxidized molecules and trigger inflammatory responses by macrophages. Using a mouse model of doxorubicin (DOX)-induced tissue injury, we previously found that the major sources of circulating EVs are from heart and liver, organs that are differentially affected by DOX. Here, we investigated the effects of...
Paper Details
Title
Extracellular vesicle-mediated macrophage activation: An insight into the mechanism of thioredoxin-mediated immune activation
Published Date
Sep 1, 2019
Journal
Volume
26
Pages
101237 - 101237
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