Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice
Abstract
Mucosal-associated invariant T (MAIT) cells and invariant NK T (iNKT) cells account for the major lymphocyte populations that express invariant TCRα-chains. MAIT cells mostly express the TCRVα19-Jα33 TCR in mice and the TCRVα7.2-Jα33 TCR in humans, whereas iNKT cells express the TCRVα14-Jα18 TCR in mice and the TCRVα24-Jα18 TCR in humans. Both MAIT and iNKT cells have the capacity to quickly produce a variety of cytokines in response to agonist...
Paper Details
Title
Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice
Published Date
Jun 1, 2019
Journal
Volume
3
Issue
6
Pages
203 - 207
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