T‐cell receptor sequencing demonstrates persistence of virus‐specific T cells after antiviral immunotherapy
Abstract
Viral infections are a serious cause of morbidity and mortality following haematopoietic stem cell transplantation (HSCT). Adoptive cellular therapy with virus-specific T cells (VSTs) has been successful in preventing or treating targeted viruses in prior studies, but the composition of ex vivo expanded VST and the critical cell populations that mediate antiviral activity in vivo are not well defined. We utilized deep sequencing of the T-cell...
Paper Details
Title
T‐cell receptor sequencing demonstrates persistence of virus‐specific T cells after antiviral immunotherapy
Published Date
Jun 20, 2019
Volume
187
Issue
2
Pages
206 - 218
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