Class I and II Aminoacyl‐tRNA Synthetase tRNA Groove Discrimination Created the First Synthetase–tRNA Cognate Pairs and Was Therefore Essential to the Origin of Genetic Coding

Published: Jun 13, 2019
Abstract
The genetic code likely arose when a bidirectional gene replicating as a quasi-species began to produce ancestral aminoacyl-tRNA synthetases (aaRS) capable of distinguishing between two distinct sets of amino acids. The synthetase class division therefore necessarily implies a mechanism by which the two ancestral synthetases could also discriminate between two different kinds of tRNA substrates. We used regression methods to uncover the possible...
Paper Details
Title
Class I and II Aminoacyl‐tRNA Synthetase tRNA Groove Discrimination Created the First Synthetase–tRNA Cognate Pairs and Was Therefore Essential to the Origin of Genetic Coding
Published Date
Jun 13, 2019
Journal
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