The p52 isoform of SHC1 is a key driver of breast cancer initiation
Abstract
SHC1 proteins (also called SHCA) exist in three functionally distinct isoforms (p46SHC, p52SHC, and p66SHC) that serve as intracellular adaptors for several key signaling pathways in breast cancer. Despite the broad evidence implicating SHC1 gene products as a central mediator of breast cancer, testing the isoform-specific roles of SHC1 proteins have been inaccessible due to the lack of isoform-specific inhibitors or gene knockout models.Here,...
Paper Details
Title
The p52 isoform of SHC1 is a key driver of breast cancer initiation
Published Date
Jun 15, 2019
Journal
Volume
21
Issue
1
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