Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis
Abstract
Recently developed DNA base editing methods enable the direct generation of desired point mutations in genomic DNA without generating any double-strand breaks1-3, but the issue of off-target edits has limited the application of these methods. Although several previous studies have evaluated off-target mutations in genomic DNA4-8, it is now clear that the deaminases that are integral to commonly used DNA base editors often bind to RNA9-13. For...
Paper Details
Title
Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis
Published Date
Jun 10, 2019
Journal
Volume
571
Issue
7764
Pages
275 - 278
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