Deep learning of the regulatory grammar of yeast 5' untranslated regions from 500,000 random sequences.

Volume: 27, Issue: 12, Pages: 2015 - 2024
Published: Nov 2, 2017
Abstract
Our ability to predict protein expression from DNA sequence alone remains poor, reflecting our limited understanding of cis-regulatory grammar and hampering the design of engineered genes for synthetic biology applications. Here, we generate a model that predicts the protein expression of the 5' untranslated region (UTR) of mRNAs in the yeast Saccharomyces cerevisiae. We constructed a library of half a million 50-nucleotide-long random 5' UTRs...
Paper Details
Title
Deep learning of the regulatory grammar of yeast 5' untranslated regions from 500,000 random sequences.
Published Date
Nov 2, 2017
Volume
27
Issue
12
Pages
2015 - 2024
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