Prediction of tablet characteristics based on sparse modeling for residual stresses simulated by the finite element method incorporating Drucker-Prager cap model

Effects of residual stresses on the mechanical characteristics of tablets such as tensile strength (TS) and disintegration time (DT) were investigated. The residual stresses were simulated using the finite element method (FEM), in which the powder compaction was represented by a Drucker-Prager cap (DPC) model under unconstrained condition. As model tablet formulations, we employed powder mixtures comprising various quantities of lactose (LAC),...