ECM Cross-Linking Regulates Invadopodia Dynamics
Abstract
Invadopodia are membrane protrusions dynamically assembled by invasive cancer cells in contact with the extracellular matrix (ECM). Invadopodia are enriched by the structural proteins actin and cortactin as well as metalloproteases such as MT1-MMP, whose function is to degrade the surrounding ECM. During metastasis, invadopodia are necessary for cancer cell intravasation and extravasation. Although signaling pathways involved in the assembly and...
Paper Details
Title
ECM Cross-Linking Regulates Invadopodia Dynamics
Published Date
Mar 1, 2018
Journal
Volume
114
Issue
6
Pages
1455 - 1466
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