Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system
Abstract
Activation of G-protein coupled receptors elevates cAMP levels promoting dissociation of protein kinase A (PKA) holoenzymes and release of catalytic subunits (PKAc). This results in PKAc-mediated phosphorylation of compartmentalized substrates that control central aspects of cell physiology. The mechanism of PKAc activation and signaling have been largely characterized. However, the modes of PKAc inactivation by regulated proteolysis were...
Paper Details
Title
Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system
Published Date
Jun 12, 2019
Journal
Volume
10
Issue
1
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History