A 4R tauopathy develops without amyloid deposits in aged cat brains
Abstract
Human tauopathies are neurodegenerative diseases with accumulation of abnormally phosphorylated and aggregated tau proteins forming neurofibrillary tangles. We investigated the development of tau pathology in aged cat brains as a model of neurofibrillary tangle formation occurring spontaneously during aging. In 4 of 6 cats aged between 18 and 21 years, we found a somatodendritic accumulation of phosphorylated and aggregated tau in neurons and...
Paper Details
Title
A 4R tauopathy develops without amyloid deposits in aged cat brains
Published Date
Sep 1, 2019
Journal
Volume
81
Pages
200 - 212
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