Original paper

Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice

Volume: 16, Issue: 20, Pages: 1870 - 1884
Published: Sep 14, 2017
Abstract
The SPO11-generated DNA double-strand breaks (DSBs) that initiate meiotic recombination occur non-randomly across genomes, but mechanisms shaping their distribution and repair remain incompletely understood. Here, we expand on recent studies of nucleotide-resolution DSB maps in mouse spermatocytes. We find that trimethylation of histone H3 lysine 36 around DSB hotspots is highly correlated, both spatially and quantitatively, with trimethylation...
Paper Details
Title
Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice
Published Date
Sep 14, 2017
Journal
Volume
16
Issue
20
Pages
1870 - 1884
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