A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans
Abstract
How multicellular organisms respond to and are impacted by severe hypothermic stress is largely unknown. From C. elegans screens for mutants abnormally responding to cold-warming stimuli, we identify a molecular genetic pathway comprising ISY-1, a conserved uncharacterized protein, and ZIP-10, a bZIP-type transcription factor. ISY-1 gatekeeps the ZIP-10 transcriptional program by regulating the microRNA mir-60. Downstream of ISY-1 and mir-60,...
Paper Details
Title
A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans
Published Date
Apr 17, 2018
Journal
Volume
7
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