Apoptosis of cancer cells is triggered by selective crosslinking and inhibition of receptor tyrosine kinases
Abstract
Receptor tyrosine kinases (RTK) have been the most prevalent therapeutic targets in anti-cancer drug development. However, the emergence of drug resistance toward single target RTK inhibitors remains a major challenge to achieve long-term remissions. Development of alternative RTK inhibitory strategies that bypass drug resistance is much wanted. In the present study, we found that selected cell surface RTKs were inhibited and crosslinked into...
Paper Details
Title
Apoptosis of cancer cells is triggered by selective crosslinking and inhibition of receptor tyrosine kinases
Published Date
Jun 21, 2019
Journal
Volume
2
Issue
1
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