Growth Factor–like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells

Volume: 202, Issue: 4, Pages: 1287 - 1300
Published: Feb 15, 2019
Abstract
Recurrent mutational activation of the MAP kinase pathway in plasma cell myeloma implicates growth factor–like signaling responses in the biology of Ab-secreting cells (ASCs). Physiological ASCs survive in niche microenvironments, but how niche signals are propagated and integrated is poorly understood. In this study, we dissect such a response in human ASCs using an in vitro model. Applying time course expression data and parsimonious gene...
Paper Details
Title
Growth Factor–like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells
Published Date
Feb 15, 2019
Volume
202
Issue
4
Pages
1287 - 1300
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