A Pan-Cancer Catalogue of Cancer Driver Protein Interaction Interfaces
Volume: 11, Issue: 10, Pages: e1004518 - e1004518
Published: Oct 20, 2015
Abstract
Despite their importance in maintaining the integrity of all cellular pathways, the role of mutations on protein-protein interaction (PPI) interfaces as cancer drivers has not been systematically studied. Here we analyzed the mutation patterns of the PPI interfaces from 10,028 proteins in a pan-cancer cohort of 5,989 tumors from 23 projects of The Cancer Genome Atlas (TCGA) to find interfaces enriched in somatic missense mutations. To that end...
Paper Details
Title
A Pan-Cancer Catalogue of Cancer Driver Protein Interaction Interfaces
Published Date
Oct 20, 2015
Journal
Volume
11
Issue
10
Pages
e1004518 - e1004518
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