Original paper
Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III
Abstract
Lipid droplets (LDs) are neutral lipid storage organelles that transfer lipids to various organelles including peroxisomes. Here, we show that the hereditary spastic paraplegia protein M1 Spastin, a membrane-bound AAA ATPase found on LDs, coordinates fatty acid (FA) trafficking from LDs to peroxisomes through two interrelated mechanisms. First, M1 Spastin forms a tethering complex with peroxisomal ABCD1 to promote LD–peroxisome contact...
Paper Details
Title
Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III
Published Date
Jun 21, 2019
Journal
Volume
218
Issue
8
Pages
2583 - 2599
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Notes
History