Original paper

Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

Volume: 218, Issue: 8, Pages: 2583 - 2599
Published: Jun 21, 2019
Abstract
Lipid droplets (LDs) are neutral lipid storage organelles that transfer lipids to various organelles including peroxisomes. Here, we show that the hereditary spastic paraplegia protein M1 Spastin, a membrane-bound AAA ATPase found on LDs, coordinates fatty acid (FA) trafficking from LDs to peroxisomes through two interrelated mechanisms. First, M1 Spastin forms a tethering complex with peroxisomal ABCD1 to promote LD–peroxisome contact...
Paper Details
Title
Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III
Published Date
Jun 21, 2019
Volume
218
Issue
8
Pages
2583 - 2599
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