Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization
Abstract
The extent to which changes in gene expression can influence cardiovascular disease risk across different tissue types has not yet been systematically explored. We have developed an analysis pipeline that integrates tissue-specific gene expression, Mendelian randomization and multiple-trait colocalization to develop functional mechanistic insight into the causal pathway from a genetic variant to a complex trait. We undertook an expression...
Paper Details
Title
Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization
Published Date
Jan 31, 2019
Journal
Volume
11
Issue
1
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