The evolution of CHC22 clathrin influences its role in human glucose metabolism

Pages: 307264
Published: Aug 21, 2018
Abstract
CHC22 clathrin plays a key role in intracellular membrane trafficking of the insulin-responsive glucose transporter GLUT4, and so in post-prandial clearance of glucose from human blood. We performed population genetic and phylogenetic analyses of the CLTCL1 gene, encoding CHC22, to gain insight into its functional evolution. Analysis of 58 vertebrate genomes showed independent loss of CLTCL1 in at least two lineages after it arose from a gene...
Paper Details
Title
The evolution of CHC22 clathrin influences its role in human glucose metabolism
Published Date
Aug 21, 2018
Journal
Pages
307264
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