Abnormal platelet amyloid‐β precursor protein metabolism in SAMP8 mice: Evidence for peripheral marker in Alzheimer's disease

Senescence‐accelerated mouse strains have proved to be an accelerated‐aging model, which mimics numerous features with Alzheimer's disease (AD). Three, six, and nine‐month senescence‐accelerated resistant 1 and senescence‐accelerated prone 8 (SAMP8) mice were used in the current study, to unravel potential mechanisms for dementia and explore new diagnostic approaches for AD. The amyloid‐β (Aβ40) and Aβ42 levels were elevated in hippocampi and...