Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution
Abstract
Noncoding regulatory variants play a central role in the genetics of human diseases and in evolution. Here we measure allele-specific transcription factor binding occupancy of three liver-specific transcription factors between crosses of two inbred mouse strains to elucidate the regulatory mechanisms underlying transcription factor binding variations in mammals. Our results highlight the pre-eminence of cis-acting variants on transcription...
Paper Details
Title
Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution
Published Date
Oct 23, 2017
Journal
Volume
8
Issue
1
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