Digoxin–mortality: randomized vs. observational comparison in the DIG trial
Abstract
Aims The Digitalis Investigation Group (DIG) trial, the only large randomized trial of digoxin in heart failure, reported a neutral effect on mortality and a significant reduction in heart failure hospitalizations. Recent observational studies reported increased mortality with digoxin treatment. We present further analyses of the DIG trial displaying the inability to control bias in observational treatment comparisons despite extensive...
Paper Details
Title
Digoxin–mortality: randomized vs. observational comparison in the DIG trial
Published Date
Jun 18, 2019
Journal
Volume
40
Issue
40
Pages
3336 - 3341
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