Inflammasome as a promising therapeutic target for cancer
Abstract
Inflammasomes are the major mechanistic complexes that include members of the NOD-like receptor (NLRs) or AIM2-like receptors (ALRs) families, which are affiliated with the innate immune system. Once NLRs or ALRs are activated by pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs), the caspase-1 or -11 is activated by binding with NLRs or ALRs via its own unique cytosolic domains. As a result, caspase-1...
Paper Details
Title
Inflammasome as a promising therapeutic target for cancer
Published Date
Aug 1, 2019
Journal
Volume
231
Pages
116593 - 116593
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