OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin
Abstract
Asprosin is a fasting-induced hormone that promotes glucose production in the liver and stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an unknown G protein-coupled receptor (GPCR). However, the bona fide receptor of Asprosin is unclear. Here, we have identified that the olfactory receptor OLFR734 acts as a receptor of Asprosin to modulate hepatic glucose production. Olfr734 knockout mice show a blunted...
Paper Details
Title
OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin
Published Date
Aug 1, 2019
Journal
Volume
30
Issue
2
Pages
319 - 328.e8
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