Pulmonary vascular density: comparison of findings on computed tomography imaging with histology

Exposure to cigarette smoke has been shown to lead to vascular remodelling. Computed tomography (CT) imaging measures of vascular pruning have been associated with pulmonary vascular disease, an important morbidity associated with smoking. In this study we compare CT-based measures of distal vessel loss to histological vascular and parenchymal changes.A retrospective review of 80 patients who had undergone lung resection identified patients with...