A thermostable Cas9 with increased lifetime in human plasma
Abstract
CRISPR-Cas9 is a powerful technology that has enabled genome editing in a wide range of species. However, the currently developed Cas9 homologs all originate from mesophilic bacteria, making them susceptible to degradation and unsuitable for applications requiring cleavage at elevated temperatures. Here, we show that the Cas9 protein from the thermophilic bacterium Geobacillus stearothermophilus (GeoCas9) catalyzes RNA-guided DNA cleavage at...
Paper Details
Title
A thermostable Cas9 with increased lifetime in human plasma
Published Date
Nov 10, 2017
Journal
Volume
8
Issue
1
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