Uncoupled activation and cyclisation in catmint reductive terpenoid biosynthesis
Abstract
Terpene synthases typically form complex molecular scaffolds by concerted activation and cyclization of linear starting materials in a single enzyme active site. Here we show that iridoid synthase, an atypical reductive terpene synthase, catalyses the activation of its substrate 8-oxogeranial into a reactive enol intermediate but does not catalyse the subsequent cyclisation into nepetalactol. This discovery led us to identify a class of...
Paper Details
Title
Uncoupled activation and cyclisation in catmint reductive terpenoid biosynthesis
Published Date
Aug 14, 2018
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