Electron cryo-microscopy structure of the canonical TRPC4 ion channel.
Abstract
Canonical transient receptor channels (TRPC) are non-selective cation channels. They are involved in receptor-operated Ca2+ signaling and have been proposed to act as store-operated channels (SOC). Their malfunction is related to cardiomyopathies and their modulation by small molecules has been shown to be effective against renal cancer cells. The molecular mechanism underlying the complex activation and regulation is poorly understood. Here, we...
Paper Details
Title
Electron cryo-microscopy structure of the canonical TRPC4 ion channel.
Published Date
May 2, 2018
Journal
Volume
7
Pages
1 - 46
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