Structure of the Mouse TRPC4 Ion Channel
Abstract
Members of the transient receptor potential (TRP) ion channels conduct cations into cells. They mediate functions ranging from neuronally mediated hot and cold sensation to intracellular organellar and primary ciliary signaling. Here we report a cryo-electron microscopy (cryo-EM) structure of TRPC4 in its unliganded (apo) state to an overall resolution of 3.3 A. The structure reveals a unique architecture with a long pore loop stabilized by a...
Paper Details
Title
Structure of the Mouse TRPC4 Ion Channel
Published Date
Aug 6, 2018
Journal
Volume
9
Issue
1
Pages
3102 - 3102
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