Mechanism of IRSp53 inhibition by 14-3-3
Abstract
Filopodia are precursors of dendritic spines and polarized cell migration. The I-BAR-domain protein IRSp53 is a key regulator of filopodia dynamics that couples Rho-GTPase signaling to cytoskeleton and membrane remodeling, playing essential roles in neuronal development and cell motility. Here, we describe the structural-functional basis for 14-3-3-dependent inhibition of IRSp53. Phosphoproteomics, quantitative binding and crystallographic...
Paper Details
Title
Mechanism of IRSp53 inhibition by 14-3-3
Published Date
Jan 29, 2019
Journal
Volume
10
Issue
1
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