Understanding Tissue-Specific Gene Regulation
Abstract
Although all human tissues carry out common processes, tissues are distinguished by gene expression patterns, implying that distinct regulatory programs control tissue specificity. In this study, we investigate gene expression and regulation across 38 tissues profiled in the Genotype-Tissue Expression project. We find that network edges (transcription factor to target gene connections) have higher tissue specificity than network nodes (genes)...
Paper Details
Title
Understanding Tissue-Specific Gene Regulation
Published Date
Oct 24, 2017
Journal
Volume
21
Issue
4
Pages
1077 - 1088
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