Identification of 55,000 Replicated DNA Methylation QTL

Allan F. McRae; Riccardo E. Marioni; Sonia Shah; Jian Yang; Joseph E. Powell; Sarah E. Harris; Jude Gibson; Anjali K. Henders; Lisa Bowdler; Jodie N. Painter; Peter M. Visscher; Grant W. Montgomery

doi:https://doi.org/10.1038/s41598-018-35871-w

doi.org/10.1038/s41598-018-35871-w

Identification of 55,000 Replicated DNA Methylation QTL

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..., Grant W. Montgomery

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Scientific Reports4.60

Volume: 8, Issue: 1

Published: Dec 4, 2018

Abstract

DNA methylation plays an important role in the regulation of transcription. Genetic control of DNA methylation is a potential candidate for explaining the many identified SNP associations with disease that are not found in coding regions. We replicated 52,916 cis and 2,025 trans DNA methylation quantitative trait loci (mQTL) using methylation from whole blood measured on Illumina HumanMethylation450 arrays in the Brisbane Systems Genetics Study...

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Paper Details

Title

Identification of 55,000 Replicated DNA Methylation QTL

DOI

doi.org/10.1038/s41598-018-35871-w

Published Date

Dec 4, 2018

Journal

Scientific Reports

Volume

8

Issue

1

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