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Published on Feb 12, 2019in Biochemistry 2.95
Pratul K. Agarwal18
Estimated H-index: 18
Even after a century of investigation, our understanding of how enzymes work remains far from complete. In particular, several factors that enable enzymes to achieve high catalytic efficiencies remain only poorly understood. A number of theories have been developed, which propose or reaffirm that enzymes work as structural scaffolds, serving to bring together and properly orient the participants so that the reaction can proceed; therefore, leading to enzymes being viewed as only passive particip...
Published on May 1, 2017in Proteins
John R. Srouji5
Estimated H-index: 5
(University of California, Berkeley),
Anting Xu3
Estimated H-index: 3
(University of California, Berkeley)
+ 2 AuthorsSteven E. Brenner55
Estimated H-index: 55
(University of California, Berkeley)
Published on Jan 1, 2017in Biological Chemistry 3.01
Zrinka Karačić3
Estimated H-index: 3
,
Bojana Vukelić8
Estimated H-index: 8
+ 7 AuthorsMarija Abramić11
Estimated H-index: 11
In a search for plant homologues of dipeptidyl peptidase III (DPP III) family, we found a predicted protein from the moss Physcomitrella patens (UniProt entry: A9TLP4), which shared 61% sequence identity with the Arabidopsis thaliana uncharacterized protein, designated Nudix hydrolase 3. Both proteins contained all conserved regions of the DPP III family, but instead of the characteristic hexapeptide HEXXGH zinc-binding motif, they possessed a pentapeptide HEXXH, and at the N-terminus, a Nudix b...
Published on Jul 3, 2015in Science 41.04
Jean-Louis Magnard8
Estimated H-index: 8
(University of Lyon),
Aymeric Roccia1
Estimated H-index: 1
(University of Lyon)
+ 18 AuthorsFlorence Nicolè10
Estimated H-index: 10
(University of Lyon)
The scent of roses ( Rosa x hybrida ) is composed of hundreds of volatile molecules. Monoterpenes represent up to 70% percent of the scent content in some cultivars, such as the Papa Meilland rose. Monoterpene biosynthesis in plants relies on plastid-localized terpene synthases. Combining transcriptomic and genetic approaches, we show that the Nudix hydrolase RhNUDX1, localized in the cytoplasm, is part of a pathway for the biosynthesis of free monoterpene alcohols that contribute to fragrance i...
Published on Jan 1, 2010in Journal of Biological Chemistry
Teruya Nakamura10
Estimated H-index: 10
(Kumamoto University),
Sachiko Meshitsuka1
Estimated H-index: 1
(Osaka University)
+ 10 AuthorsYuji Kobayashi19
Estimated H-index: 19
(Osaka University)
Escherichia coli MutT hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, an event that can prevent the misincorporation of 8-oxoguanine opposite adenine in DNA. Of the several enzymes that recognize 8-oxoguanine, MutT exhibits high substrate specificity for 8-oxoguanine nucleotides; however, the structural basis for this specificity is unknown. The crystal structures of MutT in the apo and holo forms and in the binary and ternary forms complexed with the product 8-oxo-dGMP and 8-oxo-dGMP plus Mn2+, respective...
Published on Jan 1, 2009in Comparative and Functional Genomics 2.30
D. Gunawardana1
Estimated H-index: 1
,
V. A. Likic1
Estimated H-index: 1
,
Ken R. Gayler8
Estimated H-index: 8
Nudix enzymes are a superfamily with a conserved common reaction mechanism that provides the capacity for the hydrolysis of a broad spectrum of metabolites. We used hidden Markov models based on Nudix sequences from the PFAM and PROSITE databases to identify Nudix hydrolases encoded by the Arabidopsis genome. 25 Nudix hydrolases were identified and classified into 11 individual families by pairwise sequence alignments. Intron phases were strikingly conserved in each family. Phylogenetic analysis...
Published on Aug 1, 2007in Structure 4.58
Sandra B. Gabelli22
Estimated H-index: 22
(Johns Hopkins University),
Mario A. Bianchet31
Estimated H-index: 31
(Johns Hopkins University)
+ 4 AuthorsMaurice J. Bessman31
Estimated H-index: 31
(Johns Hopkins University)
Summary Nudix hydrolases are a superfamily of pyrophosphatases, most of which are involved in clearing the cell of potentially deleterious metabolites and in preventing the accumulation of metabolic intermediates. We determined that the product of the orf17 gene of Escherichia coli , a Nudix NTP hydrolase, catalyzes the hydrolytic release of pyrophosphate from dihydroneopterin triphosphate, the committed step of folate synthesis in bacteria. That this dihydroneopterin hydrolase (DHNTPase) is ind...
Published on Aug 11, 2006in Journal of Biological Chemistry
WenLian Xu12
Estimated H-index: 12
,
Christopher A. Dunn16
Estimated H-index: 16
+ 2 AuthorsMaurice J. Bessman31
Estimated H-index: 31
Abstract Three members of the Nudix (nucleoside diphosphate X) hydrolase superfamily have been cloned from Escherichia coli MG1655 and expressed. The proteins have been purified and identified as enzymes active on nucleoside diphosphate derivatives with the following specificities. Orf141 (yfaO) is a nucleoside triphosphatase preferring pyrimidine deoxynucleoside triphosphates. Orf153 (ymfB) is a nonspecific nucleoside tri- and diphosphatase and atypically releases inorganic orthophosphate from ...
Published on Feb 1, 2006in British Journal of Pharmacology 6.58
Hannu Mönkkönen22
Estimated H-index: 22
,
Seppo Auriola38
Estimated H-index: 38
+ 4 AuthorsJukka Mönkkönen49
Estimated H-index: 49
Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of diseases with excess bone resorption. On the basis of their molecular mechanism of action, bisphosphonates can be divided into two pharmacological classes; nitrogen-containing (N-BPs) and non-nitrogen-containing bisphosphonates (non-N-BP). Both classes induce apoptosis but they evoke it differently; N-BPs by inhibiting the intracellular mevalonate pathway and protein isoprenylation, and non-N...
Published on Jan 1, 2006in Cellular and Molecular Life Sciences 7.01
Alexander G. McLennan29
Estimated H-index: 29
(University of Liverpool)
Nudix hydrolases are found in all classes of organism and hydrolyse a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, dinucleoside and diphosphoinositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity. Some superfamily members, such as Escherichia coli MutT, have the ability to degrade potentially mutagenic, oxidised nucleotides while others control the levels of metabolic intermediates and signalling compounds. In p...
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