Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels

eLife7.70
Volume: 8
Published: Jul 18, 2019
Abstract
Acid-sensing ion channels have important functions in physiology and pathology, but the molecular composition of acid-activated chloride channels had remained unclear. We now used a genome-wide siRNA screen to molecularly identify the widely expressed acid-sensitive outwardly-rectifying anion channel PAORAC/ASOR. ASOR is formed by TMEM206 proteins which display two transmembrane domains (TMs) and are expressed at the plasma membrane. Ion...
Paper Details
Title
Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
Published Date
Jul 18, 2019
Journal
Volume
8
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