Identification of preexisting adaptive immunity to Cas9 proteins in humans

Volume: 25, Issue: 2, Pages: 249 - 254
Published: Jan 28, 2019
Abstract
The CRISPR–Cas9 system is a powerful tool for genome editing, which allows the precise modification of specific DNA sequences. Many efforts are underway to use the CRISPR–Cas9 system to therapeutically correct human genetic diseases1–6. The most widely used orthologs of Cas9 are derived from Staphylococcus aureus and Streptococcus pyogenes5,7. Given that these two bacterial species infect the human population at high frequencies8,9, we...
Paper Details
Title
Identification of preexisting adaptive immunity to Cas9 proteins in humans
Published Date
Jan 28, 2019
Volume
25
Issue
2
Pages
249 - 254
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