Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis
Abstract
Hepatic steatosis develops when lipid influx and production exceed the liver’s ability to utilize/export triglycerides. Obesity promotes steatosis and is characterized by leptin resistance. A role of leptin in hepatic lipid handling is highlighted by the observation that recombinant leptin reverses steatosis of hypoleptinemic patients with lipodystrophy by an unknown mechanism. Since leptin mainly functions via CNS signaling, we here examine in...
Paper Details
Title
Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis
Published Date
Jun 20, 2019
Journal
Volume
10
Issue
1
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