Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK
Abstract
Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear. Here, we show that FBP-unoccupied aldolase interacts with and inhibits endoplasmic reticulum (ER)-localized transient receptor potential channel subfamily V, inhibiting calcium release in low glucose. The decrease of...
Paper Details
Title
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK
Published Date
Sep 1, 2019
Journal
Volume
30
Issue
3
Pages
508 - 524.e12
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