Large-scale chemical–genetics yields new M. tuberculosis inhibitor classes
Abstract
New antibiotics are needed to combat rising levels of resistance, with new Mycobacterium tuberculosis (Mtb) drugs having the highest priority. However, conventional whole-cell and biochemical antibiotic screens have failed. Here we develop a strategy termed PROSPECT (primary screening of strains to prioritize expanded chemistry and targets), in which we screen compounds against pools of strains depleted of essential bacterial targets. We...
Paper Details
Title
Large-scale chemical–genetics yields new M. tuberculosis inhibitor classes
Published Date
Jun 19, 2019
Journal
Volume
571
Issue
7763
Pages
72 - 78
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