Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock
Abstract
Maintenance of epigenetic modifiers is of utmost importance to preserve the epigenome and consequently appropriate cellular functioning. Here, we analyzed Polycomb group protein (PcG) complex integrity in response to heat shock (HS). Upon HS, various Polycomb Repressive Complex (PRC)1 and PRC2 subunits, including CBX proteins, but also other chromatin regulators, are found to accumulate in the nucleolus. In parallel, binding of PRC1/2 to target...
Paper Details
Title
Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock
Published Date
Jun 14, 2019
Journal
Volume
8
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