Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling

The ankyrin 3 gene ( ANK3 ) is a well-established risk gene for psychiatric illness, but the mechanisms underlying its pathophysiology remain elusive. We examined the molecular effects of disrupting brain-specific Ank3 isoforms in mouse and neuronal model systems. RNA sequencing of hippocampus from Ank3 +/− and Ank3 +/+ mice identified altered expression of 282 genes that were enriched for microtubule-related functions. Results were supported by...