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Pyrethroid exposure alters internal and cuticle surface bacterial communities in Anopheles albimanus

Published on Jun 6, 2019in The ISME Journal9.49
· DOI :10.1038/s41396-019-0445-5
Nsa Dada2
Estimated H-index: 2
(American Society for Microbiology),
Juan C. Lol1
Estimated H-index: 1
(Universidad del Valle de Guatemala)
+ 5 AuthorsAudrey Lenhart11
Estimated H-index: 11
(CDC: Centers for Disease Control and Prevention)
Abstract
A deeper understanding of the mechanisms underlying insecticide resistance is needed to mitigate its threat to malaria vector control. Following previously identified associations between mosquito microbiota and insecticide resistance, we demonstrate for the first time, the effects of pyrethroid exposure on the microbiota of F1 progeny of field-collected Anopheles albimanus. Larval and adult mosquitoes were exposed to the pyrethroids alphacypermethrin (only adults), permethrin, and deltamethrin. While there were no significant differences in bacterial composition between insecticide-resistant and insecticide-susceptible mosquitoes, bacterial composition between insecticide-exposed and non-exposed mosquitoes was significantly different for alphacypermethrin and permethrin exposure. Along with other bacterial taxa not identified to species, Pantoea agglomerans (a known insecticide-degrading bacterial species) and Pseudomonas fragi were more abundant in insecticide-exposed compared to non-exposed adults, demonstrating that insecticide exposure can alter mosquito bacterial communities. We also show for the first time that the cuticle surfaces of both larval and adult An. albimanus harbor more diverse bacterial communities than their internal microbial niches. Together, these findings demonstrate how insecticide pressure could be selecting for certain bacteria within mosquitoes, especially insecticide-metabolizing bacteria, thus potentially contributing to insecticide resistance.
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References73
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#1Nsa Dada (American Society for Microbiology)H-Index: 1
#2Mili Sheth (CDC: Centers for Disease Control and Prevention)H-Index: 7
Last.Audrey Lenhart (CDC: Centers for Disease Control and Prevention)H-Index: 11
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#1Nicholas A. Bokulich (NAU: Northern Arizona University)H-Index: 26
#2Benjamin Kaehler (ANU: Australian National University)H-Index: 6
Last.J. Gregory Caporaso (NAU: Northern Arizona University)H-Index: 38
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#1Evan Bolyen (NAU: Northern Arizona University)H-Index: 6
#2Jai Ram Rideout (NAU: Northern Arizona University)H-Index: 11
Last.Manimozhiyan Arumugam (UCPH: University of Copenhagen)H-Index: 29
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#1Claire L. Jeffries (Lond: University of London)H-Index: 6
#2Gena G. Lawrence (CDC: Centers for Disease Control and Prevention)H-Index: 9
Last.Fara Nantenaina Raharimalala (Pasteur Institute)H-Index: 7
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#1Hui Zhan (SCAU: South China Agricultural University)H-Index: 2
#2Huishan Wang (SCAU: South China Agricultural University)H-Index: 2
Last.Shaohua Chen (SCAU: South China Agricultural University)H-Index: 18
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