Longer-Term Assessment of Azithromycin for Reducing Childhood Mortality in Africa

The MORDOR I trial (Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Résistance) showed that in Niger, mass administration of azithromycin twice a year for 2 years resulted in 18% lower postneonatal childhood mortality than administration of placebo. Whether this benefit could increase with each administration or wane owing to antibiotic resistance was unknown.In the Niger component of the MORDOR I trial, we randomly assigned 594...