Major depressive disorder-associated SIRT1 locus affects the risk for suicide in women after middle age

Volume: 278, Pages: 141 - 145
Published: Aug 1, 2019
Abstract
• Prior GWAS of female major depressive disorder (MDD) hit SIRT1 SNPs as top candidates. • We investigated the effect of MDD-associated SIRT1 SNPs in suicide completers. • SIRT1 SNPs were associated with suicide in women aged ≥50 years. • SIRT1 gene expression in DLPFC did not differ between suicides and non-suicides. • DNAJC12 gene expression in DLPFC was decreased in suicide brains. A recent genome-wide association study (GWAS) for major...
Paper Details
Title
Major depressive disorder-associated SIRT1 locus affects the risk for suicide in women after middle age
Published Date
Aug 1, 2019
Volume
278
Pages
141 - 145
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