1561-P: Associations between ß-Cell Function and Cognitive Measures Differ in Youth vs. Adults with Impaired Glucose Tolerance (IGT) or Early Type 2 Diabetes (T2D)

Insulin resistance and impaired β-cell function are associated with risk of cognitive decline in adults over 65 y of age. Their impact on cognition in youth and adults <65 y is less clear. We assessed the relationship between insulin sensitivity, β-cell function and cognition in never or briefly-treated youth (n=71, mean age 14.2±2.0, 10-18 y) and treatment-naïve adults (n=236, mean age 54.4±8.6, 26-66 y) with IGT or early T2D in the...