Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression
Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by the loss of upper and lower motor neurons. ALS exhibits high phenotypic variability including age and site of onset, and disease duration. To uncover epigenetic and transcriptomic factors that may modify an ALS phenotype, we used a cohort of Australian monozygotic twins (n = 3 pairs) and triplets (n = 1 set) that are discordant for ALS and represent...
Paper Details
Title
Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression
Published Date
Jun 4, 2019
Journal
Volume
9
Issue
1
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