Solid Tumors Challenges and New Insights of CAR T Cell Engineering
Abstract
Adoptive cell therapy using CAR T cells has emerged as a novel treatment strategy with promising results against B cell malignancies; however, CAR T cells have not shown much success against solid malignancies. There are several obstacles which diminish the efficacy of CAR T cells, but the immunosuppressive tumor microenvironment (TME) of the tumor stands out as the most important factor. TME includes Tumor-Associated Stroma, Immunosuppressive...
Paper Details
Title
Solid Tumors Challenges and New Insights of CAR T Cell Engineering
Published Date
Jun 4, 2019
Volume
15
Issue
5
Pages
619 - 636
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